PQHS 485 – Likelihood Theory & Applications

Table of Contents

I. Welcome Video

II. Course Overview at a Glance

III. Course Objectives

IV. Course Description

V. Tentative Schedule

VI. Sample Lecture

I. Welcome Video


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II. Course Overview at a Glance

Time & Place TuTh 10:00am – 11:15am, Wood Building WG73
Instructor Abdus Sattar, PhD
Office Wood building: W-G51
Teaching Assistant TBD
Office Hours Monday and Wednesday 3:00pm – 4:00pm or by appointment
E-mail/Phone: Phone: 1-216-368-1501, Email: sattar@case.edu
Course Web Page canvas.case.edu
Textbook (Required) In All Likelihood: Statistical Modeling and Inference Using Likelihood by Yudi Pawitan
Prerequisites:

  • This course is designed for advanced graduate students in Biostatistics or other quantitative sciences with background and adequate preparation in graduate-level classical statistical theory such as that contained in the Statistical Inference by Casella and Berger (2001).
  • Some programming experience. Knowledge in mathematical computing or statistical software package is helpful.
  • EPBI 482 or cross listing or permission of the instructor.
Disability Help:

If you have a disability and need help, please contact me and the Office of Educational Support Services at disability@case.edu, 216.368.5230 as early as possible in the term.

Academic Integrity:

You are expected to maintain the highest integrity in your work for this class. This includes not passing off anyone else’s work as your own, even with their permission. Your homework solutions must be your own work, not from outside sources, consistent with the university rules on academic honesty. I expect you to follow this policy scrupulously. Evidence of academic dishonesty may lead to loss of credit for the assignment, and possibly failure of the course.

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II. Course Objectives

  1. Gain proficiency in likelihood-based modeling and inferences.
  2. Hone skills by applying contemporary likelihood theory in solving statistical problems.
  3. Gain competency in computing by solving estimation problems and judging the quality of inferences via simulation study.

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III. Course Description

This course introduces contemporary likelihood theory and its applications in solving statistical problems. The course will cover maximum likelihood theory; profile-, pseudo-, quasilikelihood theory, generalized estimating equations, h-likelihood, and nonparametric smoothing. We will use these likelihood theories in modeling and inference. Although we will rely on statistical theory and mathematics, the course is more about developing statistical thought process in addressing real-world statistical challenges. We will apply computational approaches in understanding estimation and making likelihood based inferences. There will be a midterm project in this course, which will allow you to demonstrate independent statistical research working in your own content area. The course is taught at the doctoral level, and much of the theory is illustrated through applications.

Course Requirements and Grading

Homework: Homework will be assigned biweekly. There will be approximately 6 – 7 homework assignments. No late homework will be accepted unless you have a university-excused absence.

Midterm Project: There will be a midterm project, which will provide the opportunity for you to demonstrate your statistical knowledge and computational skills in model building and making statistical inferences. You will receive more detailed information on a separate handout in the 13th lecture.

Final Exam: There will be a final exam. No makeup exam is allowed for missing this exam except in the case of a university excused absence. This will be a closed book, closed note cumulative exam.

Grading Scale: The course grade will be determined according to the following:

Homework 30%
Project 40%
Final Exam 30%

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IV. Tentative Schedule

Week Day Lecture # Topic Reading*
1
Tue 1 Introduction, Ch 2 (2.1-) Handouts
Thu 2 Ch 2: Elements of likelihood inference ( -2.9) Ch 2
2
Tue 3 Ch 3: More properties of likelihood (3.1-3.5) Ch 3
Thu 4 Ch 4 Basic models and simple applications (4.1-4.7) Ch 4
3
Tue 5 Ch 4 Basic models and simple applications (4.8-4.11) Ch 4
Thu 6 Chapter 4 Continued (extra) Ch 4
4
Tue 7 Ch 5 Frequentist properties (5.1-5.6) Ch 5
Thu 8 Ch 5 Frequentist properties (5.7-5.9) Ch 5
5
Tue 9 Ch 8: Score function and Fisher Information (8.1-8.7) Ch 8
Thu 10 Ch 9 Large sample results (9.1-9.7) Ch 9
6
Tue 11 Ch 9: Large sample results (9.8-9.12) Ch 9
Thu 12 Ch 10: Dealing with nuisance parameters (10.1-10.3) Ch 10
7
Tue 13 Ch 10 Dealing with nuisance parameters (10.4-10.6) Ch 10
Thu 14 Ch 10 Dealing with nuisance parameters (10.7-10.8) Ch 10
8
Tue 15 Ch 12 EM Algorithm (12.1-12.4) Ch 12
Thu 16 Ch 12 EM Algorithm (12.5-12.7) Ch 12
9
Tue Fall Break
Thu 17 Ch 13 Robustness of likelihood specification(13.1-13.5) Ch 13
10
Tue 18 Ch 13 Robustness of likelihood specification(13.6) Ch 13
Thu 19 Ch 14 Estimating equations and quasi-likelihood(14.1-14.3) Ch 14
11
Tue 20 Ch 14 Estimating equations and quasi-likelihood(14.4-14.6) Ch 14
Thu 21 Ch 16 Likelihood of random parameters(16.1-16.3) Ch 16
12
Tue 22 Ch 17 Random and mixed effects models(17.1-17.3) Ch 17
Thu 23 Ch 17 Random and mixed effects models(17.4-17.7) Ch 17
13
Tue 24 Ch 17 Random and mixed effects models(17.8-17.10) Ch 17
Thu 25 Ch 18 Non-parametric smoothing (18.1-18.4) Ch 18
14
Tue 26 Ch 18 Non-parametric smoothing (18.5-18.8) Ch 18
Thu Thanksgiving Holiday
15
Tue 27 Ch 18 Non-parametric smoothing (18.9-18.12) Ch 18
Thu 28 Review
Tue 29 Final Exam

*Relevant handouts, articles, etc will be provided.
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VI. Sample Lecture


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Materials


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